Dr. Mario & Puzzle League

Dr. Mario & Puzzle League, also parsed Dr. Mario / Puzzle League, is a puzzle game released for the Game Boy Advance in 2005. It was developed by both Nintendo and Intelligent Systems. The game is a 2-in-1 Dr. Mario remake and Puzzle League (known as Panel de Pon in Japan). The game was released alongside the Game Boy Micro in Japan. It is the last Dr. Mario-related game to have a physical release, as all subsequent games were only made available as a digital download.

Puzzle League's name likely comes from Pokémon Puzzle League, a game based on Tetris Attack, which in turn is based on the Japan-exclusive title, Panel de Pon.

A browser game, Dr. Mario Vitamin Toss, was released as a promotional tie-in with Dr. Mario & Puzzle League.

Gameplay
Dr. Mario is aesthetically similar to Dr. Mario 64. Like Dr. Wario, an unlockable minigame from WarioWare, Inc.: Mega Microgame$!, its bottle is 13 cells tall instead of the standard 16. Puzzle League is completely changed from the original Panel de Pon. The graphics closely resemble those of the Game Boy Advance multiboot version from Nintendo Puzzle Collection.

Both games have a multi-pack multiplayer mode, but can download a demo version to another Game Boy Advance using only one cart. The demo version of Dr. Mario features limited animation and Nintendo Entertainment System-styled graphics and soundtrack. The demo version of Puzzle League features a small animal (Pupuri from Panel de Pon in Nintendo Puzzle Collection) on the side that calls out when blocks are cleared.

Both games have an unlockable mode in which the player must hold the Game Boy Advance vertically, allowing for a larger playing field. The player can unlock this mode by clearing level 20 in single player. Puzzle League's vertical mode can be unlocked if the player scores at least 10,000 points in Endless mode.